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Associate Professor Gerard Hoyne Phone: 9433 0236 |
Gerard Hoyne joined Notre Dame in 2009 and was appointed the Associate Dean of Health Sciences. Gerard completed his BSc and PhD at The University of Western Australia and has worked extensively in academic research with stints at Universities in London and Edinburgh in the United Kingdom within the field of immunology. His research work has involved multidisciplinary teams to investigate how the immune system regulates immune responses to self and foreign proteins. This has important implications in the development of autoimmune diseases such as allergy and diabetes. He has gained research grants both in Australia and overseas that amount to over $3 million dollars over the last 20 years. He has co-authored over 40 scientific manuscripts and has presented his work at national and international scientific conferences. He was a cofounding scientist of a biotechnology company that was established in Cambridge in the UK and is a named inventor on eight international patents that have been granted. Gerard is a member of the Australian Society for Immunology and has served as a State Councillor between 2008 & 2009. He has also been a member of the British Society for Immunology. Publications: (selected) Papathanasiou, P., Karsunky, H., Xu, J., Attema, J.L., Hosen, N., Sontani, Y., Hoyne GF., Smale, S.T., and Weissman, IL. 2009. Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros. Stem Cells 27:3082-92. Z. Wu, X. Jia, X-C Su, B Marzolf, P.Troisch, D. Zak, A. Hamilton, B. Whittle, D. Yu, D. Sheahan, E. Bertram, A Aderem, G. Otting, CC Goodnow & G F. Hoyne. 2008. Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity 29: 863-875. Hoyne, G.F. and Goodnow CC. (2006). The use of genome-wide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunol Rev 210: 27-39. Wong, K., Carpenter, MJ., Young, L.L., Platt, AJ., Walker, SJ., McKenzie, G., Rust, AJ.,Ward, G., Packwood, L., Wahl, K., Delriviere, L., Hoyne, GF, Gibbs, P., Champion, BR., Lamb, J. R., and Dallman M.J. (2003) Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell dependent mechanism. J. Clin Invest.112: 1741-1750. Papathanasiou, P, Perkins, A.C., Cobb, B.S., Ferrini, R., Sridharan, Hoyne, GF., R., Nelms, K.A., Smale, S.T., Goodnow, C.C. 2003. A broad role for Ikaros in blood cell differentiation revealed by an ENU-induced point mutation. Immunity 19:131-144. Hoyne, G. F., (2003). Notch signalling in the immune system. J. Leuk. Biol.74: 971-981. Stewart, G. Hoyne, G. F.,.Ahmad, S., Jarman , E. R., Wallace WAH, Harrison, DJ, Haslett, C., Lamb, J. R., Howie, S. E. (2003) Expression of the developmental Sonic hedgehog [Shh] signalling pathway is upregulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes J. Path 199:488-495. Lowrey, J., Stewart, G. A., Lindey, S., Forsyth, L.M.G., Hoyne, G. F., Hayley, S., Lamb, J. R., Howie, S. E., (2002) Shh promotes expansion of peripheral CD4+ T cell following suboptimal TCR signalling J. Immunol. 169: 1869-1875. Hoyne G.F., Le Roux I., Corsin-Jimenez M., Tan K., Dunne J., Forsyth L.M., Dallman M.J., Owen M.J., Ish-Horowicz D. & Lamb J.R. (2000) Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int. Immunol., 12, 177. |
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